VWF and malaria: It has been demonstrated that cases of severe malaria can cause severe anemia and the development of disseminated intravascular coagulation (DIC) due to alteration of blood coagulation system, such as decreased plasma antithrombin levels, elevated levels of plasminogen activator (PAI)-1, reduced levels of vWF cleaving protease, ADAM metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13) and thrombocytopaenia, with poor chances of survival [74–76].