Other experiments reported the activation of Ras-RAF-MEK-ERk stimulating the replication of Hepatitis C virus by downregulating the interferon-JAK-STAT pathway [70], while the Hepatitis B virus can regulate the RAF1 expression in HepG2.2.15 cell inducing hepatocellular carcinoma [67]. Here, SOAT1 is linked to hepatocellular carcinoma.