Cav1 can regulate the phosphorylation of LRP6 in PCa, and the interaction between them affects the Wnt-β-Catenin signaling pathway, which in turn affects the phosphorylation of IGF-1R/IR, activates the insulin/IGF-1R pathway, and indirectly affects aerobic glycolysis [89]. This evidence concerns the gene IGF1R and posterior cortical atrophy.