AICDA and B-cell chronic lymphocytic leukemia: In a recent analysis of the chronic lymphocytic leukemia (CLL) mutational landscape, two AID signatures were observed (46); one characterized by a canonical AID signature that includes C to T/G mutations at the WRC/GYW AID hotspot, as well as a noncanonical AID signature that includes A to C mutations at WA motifs, which is consistent with COSMIC signature 9.