Meanwhile, Tat-SynGAP inhibits MST1-JNK signaling pathway by inhibiting the cleavage of caspase-3 and the phosphorylation of MST1 or JNK, and promoting the expression of angiogenesis-related molecules VEGF, Ang-l to reduce the apoptosis of the neuronal and the volume of the cerebral infarction to maintain the stability of the vascular and the integrity of BBB [79]. The gene discussed is MAPK8; the disease is cerebral infarction.