TGFB1 and osteoradionecrosis: BMP-2 and TGFβ-3 are members of the same TGFβ growth factor family and are known to play a role in bone regeneration.30 Radiotherapy-mediated reduction of BMP-2 in mandibular bone tissue was shown in osteoradionecrosis models in rodents.31 Also, it has been reported that early secretion of TGFβ-3 in mandibular alveolar defects will increase osteoprogenitor cell migration in the defect area.32 Due to these characteristics, this study also investigated differences between groups.