LF promotes integrin-Gα13 interactions and supresses YAP via reduced RhoA activity (Wang et al., 2016b), whereas DF promotes active nuclear YAP via the integrin α5β1 pathway and c-Abl kinase (or ABL1) to drive downstream ICAM1 and VCAM1 expression and atherosclerosis (Li et al., 2019). This evidence concerns the gene YAP1 and atherosclerosis.