Similar findings were seen in another 13 pairs of TSC-null and TSC–add-back/wild-type cell lines from different tumor types (Supplemental Table 1), including TSC1-null BLCA cells (Supplemental Figure 2, A and B), TSC2-null angiomyolipoma cells (Supplemental Figure 2C), TSC2-null HCC cells (Supplemental Figure 2, D and E), Tsc1- and Tsc2-null mouse embryonic fibroblasts (Supplemental Figure 2, F and G), Tsc2-null mouse RCC cells (Supplemental Figure 2, H, I, and M), and Tsc1-null mouse LUAD cells (Supplemental Figure 2, J–L). Here, TSC1 is linked to hepatocellular carcinoma.