Moreover, in situ PLA showed that the interaction between DUSP8 and Pur-α was induced in the cytoplasm of the T cells from people with asthma of 2 independent cohorts (Figure 6D); the frequencies of the PLA-positive T cells were drastically increased in people with asthma compared with those of healthy controls (Figure 6E). The gene discussed is PURA; the disease is asthma.