DUSP8 and autoimmune disease: Moreover, 2 other SNPs (rs17885785 and rs1004446), mapped to the putative enhancers of the DUSP8 gene by GeneHancer database of the GeneCards website, are associated with several autoimmune diseases, including systemic lupus erythematosus, chronic childhood arthritis, psoriasis, ulcerative colitis, and type I diabetes mellitus.