Neuroinflammatory mechanisms have been implicated in both histological and transcriptomic analysis of SVD and age‐related white matter disease (Al‐Mashhadi et al., 2015; Armstrong et al., 2020; Hase et al., 2018; Persyn et al., 2020; Simpson et al., 2007; Simpson et al., 2007; Simpson et al., 2009; Waller et al., 2020; Wardlaw et al., 2019; Wharton et al., 2015), however the role of CSF1R signaling has not yet been studied. Here, CSF1R is linked to snowflake vitreoretinal degeneration.