These findings partly explain why ZNF‐148 silencing promoted breast cancer cell apoptosis in the present study and why ZNF‐148 overexpression mediated apoptotic cell death in the study by Bai et al.,3, 27 indicating different ZNF‐148 splicing isoforms may exist in breast cancer, gastrointestinal tumors, or other tumors. The gene discussed is ZNF148; the disease is breast carcinoma.