Because both miR‐335 and SOD2 are involved in regulating pyroptosis, we next explored whether ZNF‐148 modulates this progression through the miR‐335/SOD2 axis by transfecting the ZNF‐148 silencing vector, miR‐335 inhibitor, and SOD2 overexpression vector into breast cancer cells. The gene discussed is SOD2; the disease is breast carcinoma.