Along with the suppression of breast cancer malignancy in ZNF‐148‐deficient cells, the present data showed that ZNF‐148 silencing upregulated pyroptosis‐associated biomarkers (NLRP3, ASC, IL‐1β, and IL‐18) in breast cancer cells, but both miR‐335 knockdown and SOD2 overexpression abrogated the promoting effects of ZNF‐148 deficiency on breast cancer cell pyroptosis. Here, SOD2 is linked to breast cancer.