As is related to AD, the downregulated DEmiRs of let-7c-5p, mir-615-5p, mir-615-3p, and mir-196a-5p were responsible for negatively regulating apoptosis in MYC, MDM2, CCND2, PRLR, CDKN1A, and IGF1R genes in PI3K-Akt. This evidence concerns the gene PRLR and Alzheimer disease.