On the other hand, hsa-let-7c-5p, hsa-mir-205-5p, hsa-mir-196a-5p, hsa-mir-615-3p regulated XBP,25 PSMD8, TUBB, CSNK2A1 and APP,26 WIPI1 and NRAS,27 DVL3,28 CALM129 in the key pathway of AD (Supplementary Figure 4). The gene discussed is DVL3; the disease is Alzheimer disease.