As part of the ER stress response to the apoptosis pathway, BCL2L11 and BBC3 genes, as well as the BCL2L11 gene related to beta-amyloid, and the AKT1 gene that negatively regulates autophagy, which is the highest degree hub genes in the MCC model, were commonly downregulated by mir-185-5p and mir-185-3p, whereas mir-5698 was responsible for tau protein binding hub genes for MAPK1 and ACTB. Here, MAPK1 is linked to Merkel cell skin cancer.