IGF1R and Alzheimer disease: Recent studies have disclosed that plasma samples from AD patients are reduced in hsa-miR-185-5p, which has been shown to affect APP dysregulation31 and neurofibrillary pathology.32 As noted earlier, IGF1R and GSK3B in the mTOR pathway mediate the cellular response to beta-amyloid, and AKT1 and GSK3B are particularly activated in 3 pathways to regulate neuron death, among the various AD kinds that are associated to 10 genes.