A gene sequencing of 6 SET-CAN/NUP214 positive T-ALL patients by Dai HP et al.(Jiangsu Institute of Hematology, China) showed most T-ALL patients with positive fusion gene have NOTCH1 mutations(5/6,83.3%) and PHF6 mutations(4/6,66.7%) (20). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.