A study has confirmed that enhanced protective autophagy could be one of the mechanisms leading to EGFR-TKI resistance in NSCLC, and knocking down or inhibiting EZH2 in NSCLC cells led to increased autophagy, indicating that EZH2 acts as a negative regulator of autophagy (70). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.