EZH2 and adenocarcinoma: It’s worth noting that high EZH2 expression was notably linked with several clinicopathological characteristics, including non-adenocarcinoma histology (P = 0.001), moderate and low differentiation (P = 0.001), advanced pathological tumor classification (P = 0.02), and elevated Ki-67 and cell cycle protein E labeling index (P < 0.001) (77).