EZH2 and breast carcinoma: Phosphorylation of threonine 416 by cyclin-dependent kinase 2 promotes the recruitment of EZH2 at the target gene promoter, while methylation of lysine 307 (K307) by SMYD2 enhances the stability of EZH2 and promotes breast cancer cell proliferation, epithelial mesenchymal transition, and invasion (32, 33).