TP53 and B-cell chronic lymphocytic leukemia: The main treatment used for CLL is chemotherapy, monoclonal antibodies and stem cells transplantation, which depends on: the age of patient (< 65 years vs ≥ 65 years), clinical status fit or unfit, the Cumulative Illness Rating Scale (CIRS) score, the existence or absence of a 17p deletion and/or the presence of TP53 mutations.