Both EH-JAP and EH-LEU can alleviate hyperuricaemia and kidney inflammation in mice with diet-induced hyperuricaemia, possibly by inhibiting the TLR4/MyD88/NF-κB signalling pathway, thereby inhibiting uric acid biosynthesis and promoting its excretion (Wan et al., 2020). This evidence concerns the gene MYD88 and hyperuricemia.