Thus,Feuillard and colleagues found that in patients with chronic lymphocyticleukemia (CLL), atypical tumor cells and the low level of CD45 on their surfaceare positive markers of patient survival[62].Loss of CD45 was detected in patients with Hodgkinlymphoma [63] and childhood acutelymphoblastic leukemia (ALL) [64]. This evidence concerns the gene PTPRC and neoplasm.