For the top 20 up-regulated DEPs (Figure 2A; Table S3), seven of eight shared DEPs were associated with inflammation/immune response (CRP, APMAP, C3, B2RA39, PF4, LBP and IGFBP2), indicating increased inflammatory response in TB patients regardless of SNPT or SPPT. The gene discussed is IGFBP2; the disease is tuberculosis.