To further investigate whether 1α,25(OH)2D3/FBP1 signaling could reverse insulin resistance by directly modulating γδ T cells, HFD mice were treated with anti-mouse TCRγ/δ antibody to deplete γδ+ T cells under MB05032 and 1α,25(OH)2D3 treatment. Here, FBP1 is linked to Insulin resistance.