To determine whether 1α,25(OH)2D3/FBP1 signaling could alleviate insulin resistance through γδ T cells, HFD mice were treated with anti-mouse TCRγ/δ antibody, FBP1 inhibitor MB05032, 1α,25(OH)2D3, alone or in combination (Figure 6A). Here, FBP1 is linked to Insulin resistance.