C4A and neoplasm: The dose-normalized simulation of both C4 formats kinetic in the tumor considering a single intravenous injection and FUS-induced BBB disruption shows that tumor IgG exposure overtime was higher for the 89Zr-DFO-C4 (AUC0-168h, C4 = 433 μg*h/mL) compared to the mutated IgG (AUC0-168h, C4(Fc-MUT) =247 μg*h/mL) (Figure 4).