CD4 and neoplasm: Compared to Iso-Fulips without the T cells-targeting function, the presence of T-Fulips contributed to a much significant increase in the T1 signal change in the tumor area, a rise in the percentage of effector T cells (CD45+CD4+IFN-γ+, CD45+CD8+IFN-γ+, CD45+CD4+IFN-γ+SH+, and CD45+CD8+IFN-γ+SH+), as well as a superior tumor growth suppression effect.