The average tumor weight of the TRAMP-C1-bearing mice treated with HCSVs reduced from 1.4 ± 0.3 g to 0.4 ± 0.3 g compared to 3.1 ± 0.2 g in the PBS-treated control group; the percentage of mature CD80+CD86+ DCs in lymph nodes increased from 27.9 ± 0.9% to 35.88 ± 1.8%; the proportion of infiltrated CD8+ T cells increased from 4.3 ± 0.5% to 7.7 ± 0.8% in the tumor area, and from 43.4 ± 0.9% to 46.2 ± 1.9% in lymph nodes (Figure 9) 181. The gene discussed is CD8A; the disease is neoplasm.