Two GSH-activatable molecular structures (1-Zn-PPA and 1-NLG) were prepared by covalently conjugating photosensitizers Zn-PPA-SH or IDO inhibitors NLG919 to the 2-Gd molecular backbone with a disulfide bond, respectively; MRI agents Gd-DOTA, hydrophobic fluorophores AO-Luc, and tumor-targeting ligands cRGD were integrated into the molecular backbone. The gene discussed is IDO1; the disease is neoplasm.