Second, the expression of macrophage Piezo1 was detected in human and murine fibrotic liver samples and myeloid-specific deletion of Piezo1 (Piezo1ΔLysM) mice were generated to elucidate functions of macrophage Piezo1 in liver fibrosis induced by bile duct ligation (BDL) and carbon tetrachloride (CCl4) injection. Here, PIEZO1 is linked to Hepatic fibrosis.