While weak Tet1 staining was found in the proximal tubular cells, distal tubular cells, and collecting tubular cells under non-injury conditions, significantly increased nuclear Tet1 staining was found in these tubular cells at the AKI stage and the AKI to CKD stage in injured female mice (Figure 1C-D and Figure S1E). Here, TET1 is linked to acute kidney injury.