The further downregulated peroxisome pathway in injured Tet1 KO female mice caught our attention (Figure 3B), since the kidney is rich in peroxisomes containing antioxidant enzymes, particularly superoxide dismutase (SODs) and catalase (Cat), to regulate cellular redox homeostasis; while disrupted redox homeostasis is an important pathogenic driver in AKI 43, 44. Here, CAT is linked to acute kidney injury.