Although the Tet1 level was relatively low in non-injured kidneys, Tet1 was significantly increased at day 3 and day 7 (AKI stage, I/R 3D and I/R7D), and remained high at day 21 (AKI to CKD stage, I/R 21D) after I/R injury in female mice (Figure 1A). Here, TET1 is linked to chronic kidney disease.