CD19 and neoplasm: The intrinsic T cell effector functions of huC825-expressing CAR Ts were preserved; 19BBz Ts, huC825s-19BBz, and huC825-19BBz T cells showed similar cytolytic capacity against CD19+ Raji tumor cells in vitro (Figure 1C), demonstrating that T cell killing depends on the cell surface expression of the CD19 CAR and is not altered by the expression of huC825.