For instance, by using CRISPR-mediated gene editing in zebrafish, Ablain et al. (2018) defined the sprouty-related EVH1 domain-containing 1 (SPRED1) gene, a negative regulator of the RAS-MAPK pathway, as a potent tumor suppressor in mucosal melanoma. The gene discussed is SPRED1; the disease is mucosal melanoma.