Another ADR that is also associated with HLA-B*15:02 and anti-epileptic drugs and HLA-B*58:01 and allopurinol, but also in carbamazepine initiators with HLA-A*31:01 is drug reaction with eosinophilia and systemic symptoms (DRESS) (Yip et al., 2012; Wu et al., 2016). The gene discussed is HLA-B; the disease is Increased total eosinophil count.