HLA-B and toxic epidermal necrolysis: The positive predictive value (PPV) for developing HLA-B*57:01-associated flucloxacillin-induced DILI is 0.11% (Daly et al., 2009), and for HLA-B*58:01-associated allopurinol-induced SJS/TEN the PPV is 5.5% (Lonjou et al., 2008).