Whereas some tumor associated NKT cell activating antigens have been identified (cardiolipin, PC, iGb3 and NGcGM3), a significant proportion of the antigens seem to be immune regulatory, i.e., tumors may be skewing malleable NKT cells to generate anti-inflammatory pro-tumorigenic responses (LPC, Gg3Cer, and GD3). The gene discussed is PC; the disease is neoplasm.