IL22 and atrial fibrillation: Metagenomic analysis of functional bacterial genes defined 32 dominant Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that were markedly different between AF and AF+IL-22 groups, among which 12 KEGG pathways were more abundant in AF group and 20 KEGG pathways were more abundant in AF+IL-22 group (Figure 5B).