Although toxicity has not been observed in humans where CpG ODNs were used as vaccine adjuvants (47), these markers were assessed for monitoring the development of AEs: ANA, for autoantibodies against a nuclear component of the cell; anti-dsDNA antibodies, rare in healthy subjects but highly specific for the diagnosis of Systemic Lupus Erythematosus (SLE); ANCA, known marker for the diagnosis of vasculitis. Here, BTG3 is linked to systemic lupus erythematosus.