CAV1 and pulmonary arterial hypertension: Further analysis of the dependence of Cav-1 expression on lung EC survival in Sch-PAH using our recently generated conditional lineage tracing EC-specific Cav1−/− mice (Supplementary Figures 2A–C) indicated that EC-Cav-1 deletion had no significant impact on the overall % of eGFP+ cells at baseline (Figures 2F, G), with the EC control (i.e., green ECs expressing Cav-1) and EC-Cav1−/− displaying 56% and 65% of GFP, respectively.