More recently, several inhibitory receptors have been described in NK cells: LAG-3 (lymphocyte-3 activation gene), which binds to LSECtin (liver and lymph node sinusoidal endothelial cell C-type lectin) on tumor cells, TIM-3 (mucin domain-containing protein 3), which binds to multiple ligands such as galectin-9, HMGB1, Ceacam-1 and Phosphatidylserine, and PD-1, which binds to PD-L1 (programmed death-ligand) (3). This evidence concerns the gene LAG3 and neoplasm.