CD8A and type 1 diabetes mellitus: Studies on diabetes antigen-specific CD8+ T-cells from the peripheral blood of people with T1D displayed remarkably heterogenous phenotypes both within and between individuals, including naïve, memory and exhausted phenotypes (60) as well as effector and stem cell memory T-cells (TSCM) phenotypes that were enriched in people with T1D compared to controls (8).