We found that some genes showed a downward trend in terms of their expression by podocytes in the NS-IgAN group, including the canonical marker genes (NPHS1 and CLIC5), the genes encoding membranous nephropathy-associated autoantigens (PLA2R1 and THSD7A), and genes that have not been extensively investigated in podocytes, such as PCOLCE2 and PTGDS (Figure 4C). The gene discussed is CLIC5; the disease is membranous glomerulonephritis.