In contrast, red blood cell count (p = 0.093), hemoglobin level (p = 0.272), alanine aminotransferase (ALT; p = 0.291), creatine (p = 0.296), prothrombin time (PT; p = 0.817), the percentage of male (p = 0.961), smoking (p = 0.478) or alcohol history (p = 0.934), MLS (p = 0.206), and comorbidities, including COPD (p = 0.542), HTN (p = 0.082), CAD (p = 0.916), and DM (p = 0.076), remained stable across all groups (p > 0.05; Table 1). This evidence concerns the gene F2 and chronic obstructive pulmonary disease.