AVEN and cancer: AVEN was highly expressed in six types of cancer compared to normal tissue: colon adenoma (COAD), Kidney renal clear cell carcinoma (KIRC), Kidney renal papillary cell carcinoma (KIRP), Lung adenocarcinoma (LUAD), Lung squamous cell carcinoma (LUSC), and Thyroid carcinoma (THCA) (Figure 2A).