EGFR (HER1 or ErbB1) is a transmembrane tyrosine kinase located on chromosome band 7p12. EGFR has a central role in cell division, migration, adhesion, differentiation, and apoptosis and is considered the most prominent oncogenes in IDH-WT glioblastomas (Figure 1). The gene discussed is EGFR; the disease is glioblastoma.