PRL and amenorrhea: Regarding the form of clinical presentation, we observed secondary amenorrhea in the female patient (case 2) with prolactin secreting PA, growth retardation in 2 patients with prolactin-secreting PA (cases 1,3) one of whom also presented galactorrhea, 2 patients with gigantism with growth hormone secreting PA (cases 4,5), one with headache with non-producing PA (case 6) and another patient with symptoms of polyuria and primary polydipsia (3L/day) with FSH secreting PA (case 7) (Table 1).