In the adolescent population adenomas present greater aggressiveness since in 5% there is some association with family syndromes such as Familial Isolated Pituitary Adenomas (FIPA), with MEN1 being among the most frequent, and the other 95% present pathogenic variants to somatic lines of the GNAS gene [2, 9, 13]. This evidence concerns the gene GNAS and familial isolated pituitary adenoma.