NFKB1 and Stroke: TLR4/NF-κB signaling plays an essential regulatory role in stroke-induced proinflammatory microglial polarization [15, 34, 35], we tested whether the TA gel regulated anti-inflammatory microglial polarization by inhibiting the activation of the TLR4/NF-κB signaling pathway in PT stroke models in vitro and in vivo.