AKT1 and neoplasm: It is known that the main pathways involved in macrophage polarization such as notch, interferon regulatory factor (IRF), Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT), phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB/Akt) and Toll-like receptor agonists have been used to convert pro-tumor M2 TAMs into anti-tumor M1 macrophages [10].