In addition, exosomes secreted by chronic lymphocytic leukemia (CLL) induce migration and angiogenesis by transferring chloride intracellular channel 1 to HUVECs to activate the ITGβ1-MAPK/ERK signaling cascade, which provides a novel target for CLL treatment [143]. Here, ITGB1 is linked to B-cell chronic lymphocytic leukemia.