Additional ICD-related immunostimulatory signaling comprises the release of tumor cell-derived genomic and mitochondrial DNA into the cytosol of cancer cells (or their uptake by antigen presenting cells present in the tumor microenvironment) that then induce the cyclic GMP-AMP synthase (CGAS)/stimulator of interferon response CGAMP interactor 1 (STING1) pathway, as well as the liberation of transcription factor A, mitochondrial (TFAM), which serves as a ligand for advanced glycosylation end-product specific receptor (AGER), thus further stimulating DC maturation [22, 23]. Here, CGAS is linked to neoplasm.