CD4 and neoplasm: Moreover, we show the different effects of the association of RT and MRTX1257 in reshaping the tumor immune microenvironment, i.e. the important down-regulation of PD-L1 in tumor and myeloid cells, as well as the increase of the infiltration of conventional CD4+ T cells, inflammatory monocytes and dendritic cells type 2 (cDC2).