Network pharmacological indicated that some of the active extracts, such as oxymatrine, ginsenoside, and kaempferol, could regulate the pharmacological activity of TP53, TNF, VEGFA, EGFR or other key targets, and also mediate cancer, TNF, HIF-1, PI3K-Akt and some signaling pathways [122, 123]. This evidence concerns the gene TP53 and cancer.