Antigen processing and presentation (Fig. 5A), natural killer cell-mediated cytotoxicity (Fig. 5B), inflammatory response pathway (Fig. 5C), reactome signaling by interleukins (Fig. 5D), reactome interleukin 4 and interleukin 13 signaling (Fig. 5E), reactome interleukin 1 family signaling (Fig. 5F), cytokine receptor interaction (Fig. 5G), chemokine signaling pathway (Fig. 5H), and autoimmune thyroid disease (Fig. 5I) biological functions were significantly enriched in the high-risk group. Here, IL4 is linked to autoimmune thyroid disease.