To determine whether ACh-producing T-cells are required for mediating the protective effects of galantamine in acute pancreatitis, we selectively ablated ChAT expression in T-cells by crossing CD4-Cre mice with floxed ChAT mice (ChATfl/fl) to generate offspring deficient in ChAT-expressing-T cells (CD4+/ChATfl/fl) (Fig. 5A). This evidence concerns the gene CD4 and acute pancreatitis.