To the best of our knowledge, the mutations and/or dysregulation of oncogenes (e.g., KRAS, BRAF, and PIK3CA) [6] or antioncogenes (e.g., APC and PETN) [7] play an important role in the pathological process of CRC by activating carcinogenic signaling pathways, among which the PI3K/AKT pathway is an important one [8]. Here, PIK3CA is linked to colorectal carcinoma.