Vascularization is closely related to apoptosis, vascular evolution and bone regeneration.Vascularization occurs through the involvement of a variety of molecular regulators and signal transduction molecules, of which Vascular Endothelial Growth Factor (VEGF) is one of the most critical promoters, a cytokine produced by many tumor cells and other tissue cells that promotes not only intracellular neovascularization but also promote the growth and differentiation of existing blood vessels [89, 90]. Here, VEGFA is linked to neoplasm.