Functional enrichment analysis for cancer hallmark pathways revealed the upregulated genes of MΦ-C1 to be enriched in IL-6/JAK/STAT3 signaling, IL-2/STAT5 signaling, and inflammatory response, TNF-α signaling via NF-κB, hypoxia and inflammatory response in MΦ-C2, and interferon alpha response in MΦ-C3. The gene discussed is TNF; the disease is cancer.