The results showed that ‘IL-6-type cytokine receptor‒ligand interactions’, ‘NF-kB is activated and signals survival’, ‘signaling by WNT in cancer’, ‘NOTCH3 Intracellular Domain Regulates Transcription’, and ‘p75NTR signals via NF-kB’ were enriched in MΦ-C2, and MΦ-C3 was enriched in ‘PD-1 signaling’, ‘IRF3-mediated induction of type I IFN’, ‘Complement cascade’ and ‘MHC class II antigen presentation’. The gene discussed is NOTCH3; the disease is cancer.