HIF1A and obesity due to melanocortin 4 receptor deficiency: Digoxin, a cardiac glycoside that increases heart contraction forces by reversibly inhibiting the activity of the sodium-potassium ATPase pump, also identified through compound library screening as a small molecule HIF-1 inhibitor60, has been reported to prevent diet-induced obesity in mice, although the suggested mechanism is through inhibition of the IL-17A phosphorylation of PPARγ in adipocytes61.