Furthermore, Ctnnb1 expression was increased in tumours compared to both FL and RD livers and among the components of the β-catenin destruction complex, Axin1 and the known β-catenin target Axin2 was significantly upregulated, while Apc, Gsk3a and Gsk3b were not differentially expressed. The gene discussed is AXIN1; the disease is neoplasm.