TP53 and non-small cell lung carcinoma: In summary, by integrated analysis of genes alterations, GI/HRD-related events, clinicopathological characteristics and survival information of 1011 NSCLC patients, we confirmed a strong relationship between the GI/HRD score and biallelic alterations of TP53, revealed the prognostic value of the GI/HRD score in LUAD patients and developed GI-pRS for predicting survival.